منابع مشابه
Esophageal Cancer and Bisphosphonates
Volume 2 | Issue 1 At the beginning of 2009, Dianne Wysowski of the US Food and Drug Administration summarized 23 reports of esophageal cancer following alendronate use [1]. Wysowski also noted that there had been 31 cases following alendronate use in Europe and Japan and ten cases in which other bisphosphonates had been reported as concomitant or suspect treatment. Median time from exposure to...
متن کاملOral bisphosphonates and risk of esophageal cancer: a meta-analysis
Objectives: The association between oral bisphosphonate (BP) intake and esophageal cancer risk has been investigated in several recent studies with conflicting results. Methods: We conducted a detailed meta-analysis of observational studies with sub-analysis of duration, type of BPs and cumulative dose. We identified relevant studies by search of PubMed, the Cochrane Library and Embase in Octob...
متن کاملBisphosphonates and evidence for association with esophageal and gastric cancer: a systematic review and meta-analysis
OBJECTIVES Concerns have been raised about a possible link between bisphosphonate use, and in particular alendronate, and upper gastrointestinal (UGI) cancer. A number of epidemiological studies have been published with conflicting results. We conducted a systematic review and meta-analysis of observational studies, to determine the risk of esophageal and gastric cancer in users of bisphosphona...
متن کاملOral bisphosphonates and risk of esophageal cancer: a dose-intensity analysis in a nationwide population.
BACKGROUND Esophageal cancer has been associated with oral bisphosphonate use, but current data are conflicting and devoid of Asian studies where esophageal squamous carcinoma prevails. METHODS We assessed the association between dose intensity, stratified by use duration (observation period) and exposure frequency, of oral bisphosphonates and the risk of esophageal cancer using 16,204 esopha...
متن کاملOral bisphosphonates and colorectal cancer
Use of oral bisphosphonates has been associated with a decreased risk of colorectal cancer (CRC), but the association may be related to residual confounding by healthy lifestyle or body mass index (BMI). Therefore, we conducted a prospective nested case-control study within the Kaiser Permanente, Northern California health system cohort. In total, 12,505 CRC cases were individually matched to 5...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutics and Drug Development
سال: 2014
ISSN: 2348-9782
DOI: 10.15744/2348-9782.1.301